4-Carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid
MLN9708
CAS: 1201902-80-8
Molecular Formula: C20H23BCl2N2O9
4-Carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid - Names and Identifiers
4-Carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid - Physico-chemical Properties
| Molecular Formula | C20H23BCl2N2O9 |
| Molar Mass | 517.12 |
| Density | 1.47 |
| Melting Point | >227°C (dec.) |
| Solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 1.92±0.20(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| In vitro study | Compared with bortezomib, MLN9708 has a shorter separation half-life and higher pharmacokinetics, pharmacodynamics, and anticancer activity. MLN9708 is a second-generation small molecule proteasome inhibitor for the treatment of a variety of human malignant gliomas. After contact with aqueous solution and plasma, MLN9708 is rapidly hydrolyzed to mln2238. MLN2238 is the biologically active form of mln9708. MLN2238 is a nitrogen-capped dipeptide leucine boronic acid, which inhibits the chymotrypsin (β5) hydrolysis site of the 20S proteasome, with an IC50 of 3.4 nM and a K I value of 0.93 nM. At higher concentrations, MLN2238 also inhibited the caspase-like hydrolysis (β1) site and the trypsin-like hydrolysis (β2) site of the 20S proteasome with IC50 of 31 nM and 3.5 µm, respectively. MLN2238 is a potent and selective reversible inhibitor of the proteasome, and this reversibility is time-dependent. |
| In vivo study | MLN9708 has extremely high anticancer activity in solid tumors and preclinical xenografts in the blood. Recent preclinical pharmacology studies have shown that MLN9708 acts on transplanted tumors with a shorter isolation half-life, higher pharmacokinetics, pharmacodynamics, and anti-cancer activity. MLN9708 has anticancer activity on a variety of transplanted tumors. |
4-Carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29329990 |
![4-Carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid](http://res.chembk.com/assets/str/2d/1/12/1201902-80-8.png)
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Product Name: MLN9708 Request for quotation
CAS: 1201902-80-8
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CAS: 1201902-80-8
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Product Name: Ixazomib Impurity 3 Visit Supplier Webpage Request for quotationCAS: 1201902-80-8
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Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: MLN9708 Visit Supplier Webpage Request for quotation
CAS: 1201902-80-8
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 1201902-80-8
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